Nuovo interessante studio sulle proprietà della vitamina D.
Ruolo della Vitamina D nell'immunita' innata.
Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey
Adit A. Ginde, MD, MPH; Jonathan M. Mansbach, MD; Carlos A. Camargo Jr, MD, DrPH
Arch Intern Med. 2009;169(4):384-390.
In sintesi:
I livelli sierici di Viotamina D sono inversamente associati alle infezioni a carico del tratto respiratorio superiore.
Si può ipotizzare che nei soggetti con patologie respiratorie l'integrazione della vitamina D potrebbe non soltanto ridurre l'incidenza delle infezioni respiratorie, ma anche le riacutizzazioni della malattia.
venerdì 27 febbraio 2009
mercoledì 18 febbraio 2009
Vitamina D
Sono sempre più numerosi gli studi che attribuiscono alla Vitamina D un ruolo importantissimo per il mantenimento della salute. Infatti, oltre alle consolidate funzioni sul metabolismo osseo (prevenzione rachitismo, osteomalacia e osteoporosi), ultimamente sono stati pubblicati diversi lavori interessanti che portano a ritenere che un deficit di questa vitamina sia implicato in:
Malattie cardiovascolari
Giovanucci E. 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study. Arch Intern Med. 2008;168(11):1174-1180
Conclusion: Low levels of 25(OH)D are associated with higher risk of myocardial infarction in a graded manner, even after controlling for factors known to be associated with coronary artery disease.
Diabete tipo 2
Hu FB. Vitamin D and Calcium Intake in Relation to Type 2 Diabetes in Women. Diabetes Care 29: 650-656
CONCLUSIONS— The results of this large prospective study suggest a potential beneficial role for both vitamin D and calcium intake in reducing the risk of type 2 diabetes
Tumore alla prostata
Bao BY. Protective role of 1, alpha-25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells. International Journal of Cancer 2008; 122(12): 2699-2706
Together, our results showed that 1,25-VD can protect nonmalignant prostate cells from oxidative stress-induced cell death by elimination of ROS-induced cellular injuries through transcriptional activation of G6PD activity. The antioxidative effect of vitamin D strengthens its roles in cancer chemoprevention and adds to a growing list of beneficial effects of vitamin D against cancer.
Tumore al seno
Mohr SB. Relationship between Low Ultraviolet B Irradiance and Higher Breast Cancer Risk in 107 Countries The Breast Journal. Volume 14 Issue 3 Page 255-260
The dose-response gradient between modeled serum 25(OH)D levels and incidence rates of breast cancer followed a standard inverse dose-response curve. Increasing increments in serum 25(OH)D in the range above 22 ng/mL were associated with incrementally lower incidence rates of breast cancer.
Tumore al polmone
S B Mohr, C F Garland, E D Gorham, W B Grant, F C Garland. Could ultraviolet B irradiance and vitamin D be associated with lower incidence rates of lung cancer? Journal of Epidemiology and Community Health 2008;62:69-74;
Background: This study examines whether insufficient ultraviolet B (UVB) irradiance, a marker of vitamin D inadequacy, might contribute to lung cancer incidence.
CONCLUSIONS: Lower levels of UVB irradiance were independently associated with higher incidence rates of lung cancer in 111 countries.
Depressione
Witte JG. Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults. Arch Gen Psychiatry. 2008;65(5):508-512
Conclusion The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.
Malattie cardiovascolari
Giovanucci E. 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study. Arch Intern Med. 2008;168(11):1174-1180
Conclusion: Low levels of 25(OH)D are associated with higher risk of myocardial infarction in a graded manner, even after controlling for factors known to be associated with coronary artery disease.
Diabete tipo 2
Hu FB. Vitamin D and Calcium Intake in Relation to Type 2 Diabetes in Women. Diabetes Care 29: 650-656
CONCLUSIONS— The results of this large prospective study suggest a potential beneficial role for both vitamin D and calcium intake in reducing the risk of type 2 diabetes
Tumore alla prostata
Bao BY. Protective role of 1, alpha-25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells. International Journal of Cancer 2008; 122(12): 2699-2706
Together, our results showed that 1,25-VD can protect nonmalignant prostate cells from oxidative stress-induced cell death by elimination of ROS-induced cellular injuries through transcriptional activation of G6PD activity. The antioxidative effect of vitamin D strengthens its roles in cancer chemoprevention and adds to a growing list of beneficial effects of vitamin D against cancer.
Tumore al seno
Mohr SB. Relationship between Low Ultraviolet B Irradiance and Higher Breast Cancer Risk in 107 Countries The Breast Journal. Volume 14 Issue 3 Page 255-260
The dose-response gradient between modeled serum 25(OH)D levels and incidence rates of breast cancer followed a standard inverse dose-response curve. Increasing increments in serum 25(OH)D in the range above 22 ng/mL were associated with incrementally lower incidence rates of breast cancer.
Tumore al polmone
S B Mohr, C F Garland, E D Gorham, W B Grant, F C Garland. Could ultraviolet B irradiance and vitamin D be associated with lower incidence rates of lung cancer? Journal of Epidemiology and Community Health 2008;62:69-74;
Background: This study examines whether insufficient ultraviolet B (UVB) irradiance, a marker of vitamin D inadequacy, might contribute to lung cancer incidence.
CONCLUSIONS: Lower levels of UVB irradiance were independently associated with higher incidence rates of lung cancer in 111 countries.
Depressione
Witte JG. Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults. Arch Gen Psychiatry. 2008;65(5):508-512
Conclusion The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.
domenica 8 febbraio 2009
Arginina e obesità
Un nuovo studio, pubblicato sul numero di febbraio della rivista Journal of Nutrition, conferma la capacità dell'amminoacido arginina di "modulare" la risposta metabolica indirizzandola verso la crescita muscolare anzichè l'accumolo di grasso. Eloquente è la frase con cui si conclude l'abstract:
"Thus, dietary arginine supplementation shifts nutrient partitioning to promote muscle over fat gain and may provide a useful treatment for improving the metabolic profile and reducing body white fat in diet-induced obese rats."
Wenjuan Jobgen, Cynthia J. Meininger, Scott C. Jobgen, Peng Li, Mi-Jeong Lee, Stephen B. Smith, Thomas E. Spencer, Susan K. Fried, and Guoyao Wu
Dietary L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats
J. Nutr. 2009 139: 230-237.
"Thus, dietary arginine supplementation shifts nutrient partitioning to promote muscle over fat gain and may provide a useful treatment for improving the metabolic profile and reducing body white fat in diet-induced obese rats."
Wenjuan Jobgen, Cynthia J. Meininger, Scott C. Jobgen, Peng Li, Mi-Jeong Lee, Stephen B. Smith, Thomas E. Spencer, Susan K. Fried, and Guoyao Wu
Dietary L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats
J. Nutr. 2009 139: 230-237.
domenica 1 febbraio 2009
omega 3 e distress psichico
L'importanza di una adeguata assunzione di omega 3 per il mantenimento del benessere è nota da tempo. Ultimamente si fanno sempre più numerosi gli studi che dimostrano come l'EPA e il DHA siano fondamentali per il corretto funzionamento del sistema nervoso centrale. Questa capacità è confermata da un recente studio, pubblicato sul numero di febbraio 2009 dell'American Journal of Clinical Nutrition, che evidenzia come la supplementazione con omega 3 (1,05 g di EPA + 0,15 g di DHA) sia in grado di ridurre il distress psichico dopo 8 settimane in donne non affette da depressione maggiore.
Michel Lucas, Geneviève Asselin, Chantal Mérette, Marie-Josée Poulin, and Sylvie Dodin
Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial
Am J Clin Nutr 2009 89: 641-651.
Michel Lucas, Geneviève Asselin, Chantal Mérette, Marie-Josée Poulin, and Sylvie Dodin
Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial
Am J Clin Nutr 2009 89: 641-651.
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